In clinical trials, PreCardix® did not cause hypotension in any of the subjects. Once blood pressure reached healthy levels, blood pressure numbers stabilized without decreasing further. These results are consistent with the in-market data. In animal studies (rats), doses 100x the recommended daily dose did not cause hypotension or other overdose reactions.
Reference: Aluko, R., 2018. Food protein-derived peptides: Production, isolation, and purification. Proteins in Food Processing, [online] pp.389-412