Patients with pre-existing medical conditions, including renal or hepatic concerns, did not participate in the PreCardix® bioactive marine peptides clinical trial. Only healthy participants without pre-existing conditions participate in clinical trials. In the PreCardix® study serum testing of CBC, glucose, creatinine, estimated glomerular filtration rate, sodium, potassium, chloride, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transferase, and bilirubin was performed at screening and eight weeks. There were no clinically significant differences in any of these parameters in the placebo and treatment groups at baseline or end of study. All individuals, including those with a pre-existing medical condition, such as kidney or liver issues, must consult with their health care provider before initiating PreCardix®.